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Topic: NMR of two isomers  (Read 2348 times)

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Offline nehorlavazapalka

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NMR of two isomers
« on: October 28, 2013, 02:39:13 PM »
I've got two purine derivatives. One has isopropyl substituent placed at 3, while the other has isopropyl at 9.

How do I get to differentiate between them using NMR? The atoms should be eqivalent and the only thing I can think of is to use simulation software to compare the shifts, but the results are rather ambiguous.

I have 1H, 13C, COSY, HMBC and HMQC available (both compounds), though I do not understand the differences that should be there (other than different shift values).

Thank you very much for answers.


Offline Archer

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Re: NMR of two isomers
« Reply #1 on: October 28, 2013, 04:39:30 PM »
Can you discriminate between the two purine C-H protons by 1H NMR?

What C-H correlations does HMBC provide?
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