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Topic: question in NMR  (Read 2769 times)

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Offline HB

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question in NMR
« on: November 03, 2013, 02:26:45 PM »
I had reacted 4-Clphenylpiperazine with chloromethylpyridine derivative. upon running the 1HNMR, the piperazine protons appeared as only one sharp singlet signal corresponding to 8H. Is it possible for the 4 CH2 groups of piperazine to appear as only one singlet

Offline Archer

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Re: question in NMR
« Reply #1 on: November 03, 2013, 04:23:00 PM »
I had reacted 4-Clphenylpiperazine with chloromethylpyridine derivative. upon running the 1HNMR, the piperazine protons appeared as only one sharp singlet signal corresponding to 8H. Is it possible for the 4 CH2 groups of piperazine to appear as only one singlet

I would be surprised if this were the case, they are non-equivalent on either side and nitrogen heterocycles in my experience tend to be a bit of a messy multiplet. Sometimes these things can surprise you though if they are all overlapping. I can't see what other products would be formed in this reaction.

Could you post the data?

Hoe does the TLC or GC-MS data look?
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