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Topic: E2  (Read 1452 times)

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Offline Bassel

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E2
« on: December 04, 2013, 04:58:10 PM »
In case of E2; there is a question that I'm not able to understand on what base it was answered. there is an E2 reaction that makes two products, the more substituted was considered to be the MINOR. there is no case of the 3 cases of Zaitsev exceptions. the only wired thing i can see in the question is that the H of the βH has the same absolute configuration of the leaving group, which is opposite to the rule of E2 which says attack and departure on opposite absolute configurations.. so are the absolute configurations of the H and the leaving group,which is Br, causing  the more substituted to become the minor??


Offline Sophia7X

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Re: E2
« Reply #1 on: December 05, 2013, 01:13:57 AM »
Could you provide the specific example?

Also what was the base? If the base was a stericly hindered base like LDA or tert butoxide then the less substituted product will be favored.
Entropy happens.

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