I am going to try the Swern tomorrow in my lab, and was wondering if you had any tips/why it is easier? Separations easier? Thanks.
As with everything it can be substrate dependent, what are you oxidising?
You have to keep the temperature low (-60°C) but the reaction is clean and the reaction bi-products are either gaseous or pretty volatile.
Only issue with my protocol is that the excess of DMSO (2.2 molar excess) can be difficult to remove if your product is particularly volatile or water soluble.
I had to make this molecule
Which Swern did not work out for me and so I resorted to PCC in DCM.