I was stuck with my project. If anyone could please help me. thanks. I am making hydroxychalcone using acid catalysed aldol reaction. http://www.jpsr.pharmainfo.in/Documents/Volumes/Vol1Issue3/pdf/jpsr01030902.pdf
To a stirred mixture of acetophenone
(0.01mol) and benzaldehyde
(0.01mol) in absolute ethanol (5ml),
add thionyl chloride (0.05ml)
dropwise and continue stirring for
two hour at room temperature. Allow
to stand reaction mixture for 12hr.
Precipitate the reaction mixture by
addition of water. Filter the product,
wash with cold ethanol.
So acetophenone, benzaldehyde and ethanol were stirred first then thionyl chloride was added to produce HCl environment that is required.
What if thionyl chloride was added to ethanol first and stirred and then acetophenone and benzaldehyde added. Would this produce better HCl environement??
In the method it says adding thionyl chloride drop wise. If I didnt do this and added it all at once, would this be a problem??
Also, hydroxychalcones require protection of phenolic groups when in basic conditions, why don't we need that in acid catalysed reaction.
Your help will be much appreciated.