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Topic: Reaction Schemes  (Read 1569 times)

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Offline woopah94

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Reaction Schemes
« on: April 02, 2014, 01:09:48 PM »
Hey guys, struggling with this just looking for some guidance.
For my part in a group project I have to look at possible reactions that the drug "retigabine" could undergo.
I'm just wondering if anyone had an suggestions that could help, my ideas so far (literally no clue about chemistry so these are probably incorrect) maybe a possible acetylation of the NH2 group on the benzene. Possibly a hydrolysis of the carbamate functional group. If anyone else can spot another, preferably less complicated, reaction I'd really appreciate it! Here's the structure of retigabine. 




Offline critzz

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Re: Reaction Schemes
« Reply #1 on: April 02, 2014, 01:50:57 PM »
I don't know if it works, but maybe a transesterfication of the carbamate with the free -NH2 so you'll get a cyclic urea product?

5-membered rings are formed pretty fast afaik.

Offline Dan

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Re: Reaction Schemes
« Reply #2 on: April 03, 2014, 03:45:49 AM »
Lots of options here: write out a list of all the functional groups you can identify and look them up in a few organic chemistry textbooks. That should get you started.
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