In some research we are doing we are using an drug(not going to give name) that has two negative charged oxygens coming off of it. We were wanting to do a reaction that requires a phase-transfer catalyst because the said reactant is only organic soluble. To fix this we've added cyclohexyl ammonium to the negatively charged drug to then form a salt. We then added tetrabutyl-ammonium(TBA) + hydroxide to switch then conjugate the drug with TBA then making it soluble in the organic layer. Has anyone ever heard of this being done before, and if so could send me some publications related to this? We were able to get it to work just fine!!!