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anita:
When a protein is heated it gets denatured. When it is cooled it regains its conformation but there is loss of protein function. I want to know that if a protein regains its conformation on cooling, then why does it lose its function.

thallium chick:
if im reading this correct, you might just answered your own question


could it be because the heat made it loose its functioning ablilites  :)

Mitch:
As long as the active site has the same conformation as before it should still work?

Donaldson Tan:
there's a special protein in our body that can repair denatured proteins.

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