I don't quite understand the question:
Query: there are 4 chiral centers in glucose. Does each behave in the same way?
Each chiral centre? Behave the same way in what sense?
Only the typical biological one enters glycolosis, but do each of the others taste the same, but have an unfortunate ... non-absorbability?
I am not aware of any sugars (monosaccharides) that don't taste sweet, but I have not checked for data on every single one so there may be some. In terms of osmotic diarrhea, the extent to which different sugars are absorbed in the gut varies and I don't know the approximate numbers for all of them or have a comprehensive reference. L-glucose is particularly poorly absorbed and so causes diarrhea after ingestion of quite small amounts (12g is enough according to this patent
, compare to ~30 g of sucrose in a can of Coca Cola). D-Tagatose, which occurs rarely in nature and is used as a low calorie sweetener, is much more tolerated (and apparently <25% absorbed in pigs). You can see the symptoms experienced in humans, and lots of poo tables, after a 29 g tagatose breakfast here
This has to be the funniest table legend I have ever seen: TABLE 2: Distribution in Scores in Texture of the First
Defecation after the Experimental Breakfast.
I think maybe we should split this off as a separate topic Arkcon, we are veering some way from E/Z isomerism....