[Moi]

Hi all.

I have a question about which is the best way to purify an amine hydrochloride from inorganic salts. The trouble is that to prepare that hydrochloride I could not use a solution of HCl in ether or THF, and I dissolved my free base amine in THF and added an excess of aqueous HCl, so now I have my hydrochloride in a mixture of THF/water and NaCl in solution.
What do you think is the best straightforward way to eliminate the inorganic salts (NaCl) and obtain my pure hydrochloride. I would eliminate all the solvent under vacuum and do reverse phase chromatography, but in my lab I don't have the possibility to do a RPC.

Thanks,

[Hunter2]

Where is the sodium comes from. You add your amine and hydrochloride you mentioned.

[pgk]

Recuperation of the free base:
Neutralization → solvent evaporation → extraction in dichlomethane → removing of the aqueous phase → drying with Na2SO4 → dichloromethane evaporation.
Salt formation:
Solution in an oxygen containing solvent (e.g. THF, ethanol , isopropanol, etc.) → saturation with gaseous HCl at oC, (ice bath ) up to acidic to litmus (open flask in the fume cupboard) → cupping and storing in the refrigerator, overnight → filtration.
If not equipped, try an organic acid.
But, where is the sodium comes from?