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Topic: the limitation of friedel craft alkylation?  (Read 4431 times)

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bisser

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the limitation of friedel craft alkylation?
« on: April 17, 2006, 08:13:51 PM »
is friedel craft alkylation not applicable to aromatic amine?
« Last Edit: April 17, 2006, 11:14:33 PM by bisser »

saltyf

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Re: the limitation of friedel craft alkylation?
« Reply #1 on: May 19, 2006, 03:50:12 AM »
you should protect the amine first

Offline Donaldson Tan

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Re: the limitation of friedel craft alkylation?
« Reply #2 on: May 20, 2006, 09:50:24 PM »
I don't think you want the amine group to attack the reactive intermediate of the Friedel Craft Alkylation.
"Say you're in a [chemical] plant and there's a snake on the floor. What are you going to do? Call a consultant? Get a meeting together to talk about which color is the snake? Employees should do one thing: walk over there and you step on the friggin� snake." - Jean-Pierre Garnier, CEO of Glaxosmithkline, June 2006

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