[GeLe5000]

Hello.

I'd like to know if it's possible to hydrolyze proteins in hydrochloric acid at room temperature.

In the classic method, proteins are hydrolyzed in HCl 6 M at 110°C during 24 hours.

If the proteins are in HCl 6 M at 20°C during 7 days, will I get a partial hydrolysis, or is there a hindrance because of a required activation energy ?

If you have any data about the hydrolysis rate…

Thank you.

[Babcock_Hall]

I don't know of any data offhand, but the key piece of information is the free energy of activation.  My guess that that there will be a little bit of hydrolysis, but not very much.