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Solvent Systems

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rolnor:
You learn a system, how different compounds behave in it and thats why you get dogmatic. EtOAc/Toluene is a much better solvent and is similar to EtOAc/Hexane.

Babcock_Hall:
I have much less experience than some other people here.  However, I can attest to the general need to be empirical and a little creative in trying different solvent systems.

rolnor:
Agree, I was working with separation of a diastereomer derivative and we tried many systems, at last with EtOAc/DCE/Toluene we got baseline separation on silica. This way we could demonstrate a 3-fold better biological activity of one isomer over the other.

kriggy:

--- Quote from: rolnor on May 17, 2022, 04:56:32 PM ---You learn a system, how different compounds behave in it and thats why you get dogmatic. EtOAc/Toluene is a much better solvent and is similar to EtOAc/Hexane.

--- End quote ---

TBH toluene is annoying because its UV active.

Anyway, EtOAc/DCM is solid mix but I think most chemists hace the "if it works dont fix it" attitude.

rolnor:
You can use a hair-dryer or heating-gun to remove toluene, no problem.

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