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Topic: Ketone and Succinimide solution separation  (Read 1377 times)

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Offline foxfourfive

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Ketone and Succinimide solution separation
« on: March 30, 2016, 02:00:52 AM »
So I'm bromonating a non-water-soluble Ketone in Acetic Acid using NBS.

Once the reaction is complete I'm left with a reaction mixture containing the Bromo-Ketone and the Succinimide, my goal is to remove this Succinimide from the mixture completely.

Because the Succinimide is water soluble and the Ketone is not, could I dilute this mixture 1:1 with distilled water, theoretically separating the two into a Succinimide Solution and the Ketone?

Offline discodermolide

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Re: Ketone and Succinimide solution separation
« Reply #1 on: March 30, 2016, 02:25:59 AM »
I said before that chemistry is an experimental science. If you have proposed a "theory", the way to find out if it is correct is to do the experiment.
However do not forget the acetic acid.
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Offline foxfourfive

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Re: Ketone and Succinimide solution separation
« Reply #2 on: March 30, 2016, 02:38:23 AM »
Thanks for the encouragement, had a great time in the last ten minutes with that clue!  ;D

I'll put it into practice in the experiment, and have decided to neutralize the Acetic Acid with NaOH. I'm hoping that this won't affect the Bromo-Ketone.   :-\

Offline discodermolide

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Re: Ketone and Succinimide solution separation
« Reply #3 on: March 30, 2016, 03:10:09 AM »
It might be better to add water and more solvent, say dichloromethane, and do the separation. Then wash the organic with bicarbonate to remove the acetic acid. Careful of CO2 here.
NaOH, might be too strong a base.
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