April 28, 2024, 05:14:58 PM
Forum Rules: Read This Before Posting


Topic: Question about LiAlH4 reduction  (Read 1238 times)

0 Members and 1 Guest are viewing this topic.

Offline Vosegus

  • Very New Member
  • *
  • Posts: 1
  • Mole Snacks: +0/-0
Question about LiAlH4 reduction
« on: June 16, 2016, 06:52:11 AM »
Hello,
I have a carbon chain that in each of the ends I have an aldehyde group. Now I want to reduce only one of them...is it ok to use 1eq of LAH or beforehand I should put protective group on one of the akdehydes group(1eq)?
Thanks!

Offline sjb

  • Global Moderator
  • Sr. Member
  • ***
  • Posts: 3652
  • Mole Snacks: +222/-42
  • Gender: Male
Re: Question about LiAlH4 reduction
« Reply #1 on: June 16, 2016, 07:31:21 AM »
Are your aldehydes sufficiently different, or identical? If the former then there may be a regioselective way of doing this, with or without protecting groups. If identical, then it may be difficult, but perhaps take a few steps back and see if they can be differentiated earlier.

Sponsored Links