Carrying out a couple of reductive aminations on an isoprenoid tail and most of the methods use 1,2-Dichoroethane as the solvent along with some acetic acid as catalyst. I've been using DCM with no problems just interested in why DCE is the preferred solvent. I couldn't think of any reasons why DCM couldn't be used as in this prep and was wondering if my that was affecting my yields.
"Sodium triacetoxyborohydride is a general, mild, and selective reducing agent for the reductive amination of various aldehydes and ketones. 1,2-Dichloroethane (DCE) is the preferred reaction solvent, but reactions can also be carried out in tetrahydrofuran and occasionally in acetonitrile. Acetic acid may be used as catalyst with ketone reactions. Acid sensitive functional groups such as acetals and ketals, and reducible functional groups such as C-C multiple bonds and cyano and nitro groups are tolerated.
A. F. Abdel-Magid, K. G. Carson, B. D. Harris, C. A. Maryanoff, R. D. Shah, J. Org. Chem., 1996, 61, 3849-3862 "