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Topic: Primary Immunodeficiencies  (Read 6549 times)

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Offline Albert

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Primary Immunodeficiencies
« on: June 06, 2006, 06:12:29 AM »
I have a question about DiGeorge syndrome, a primary immunodeficiency which results in an impaired production of T-cells.

I just need a feedback.

Is it correct to say that, while Bruton disease is a humoral immunity deficiency (as well as hyper-M syndrome), DiGeorge syndome can be classified as a cellular immunity deficiency (as well as MHC-II class deficiency)?

Offline sdekivit

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Re: Primary Immunodeficiencies
« Reply #1 on: June 12, 2006, 04:26:09 AM »
when there's a MHC-II class deficiency, i wouldn't call it a cellular immune deficiency, since MHC-II acts on Th-cells, which signal to both B-cells as T-cells.

Offline Albert

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Re: Primary Immunodeficiencies
« Reply #2 on: June 12, 2006, 01:18:58 PM »
Finally an answer!  ;)

Thank you sdekivit!

Well, I agree with you. Moreover, primary immundeficiencies shouldn't be divided into humoral vs. cellular immunity deficiencies. Unfortunately that's the way my dull professor uses to describe them, but it's up to me to clarify that the better way to do it is to classify them into two different categories: B-cell and T-cell deficiencies.

Offline sdekivit

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Re: Primary Immunodeficiencies
« Reply #3 on: June 12, 2006, 04:09:27 PM »
about the DiGeorge' syndrome, there is a T-cell deficiency because there's no thymus gland or it is poorly developed.

--> the result is a deficiency in T-cell maturation in the thymus and thus a T-cell deficiency. This causes both cellular (cytotoxic T-cells) as humoral (T-helper-cells) immunodeficiencies.

I assume you know the processes involved in T-cell maturation ;)


Offline Albert

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Re: Primary Immunodeficiencies
« Reply #4 on: June 12, 2006, 05:01:43 PM »
Yes, I do.

All the problems came when I had to classify the diseases. I've no problem describing each of them.

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