[Pharmacist_gal]

Can anybody explain why acetaminophen recrystallises when dissolved in water/PEG/Glycerol solution? Any tips to make a stable solution please??

[Arkcon]

It may not be soluble in the mix of reagents you've selected, at the composition you've selected (that you didn't tell us.)  Paracetamol isn't very soluble in alcohols except for methanol.  And is even more poorly soluble in solvents that aren't alcohols.  Polyethylene glycol and glycerol are technically alcohols too, but may simply be too different to dissolve.  Ref: http://pubs.acs.org/doi/abs/10.1021/je990124v?journalCode=jceaax

Sounds like you're trying to make something that can be ingested.  Please follow our Forum Rules{click}, and keep this discussion theoretical.  With that caveat, where did you get this formulation of solvent?  What is its composition?  And why do you need this solvent mix, and not some other?