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Topic: Epoxide opening with dimethylamine  (Read 2423 times)

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Offline Bakterien

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Epoxide opening with dimethylamine
« on: January 10, 2018, 09:45:14 AM »
Tried to open cyclohexene oxide with dimethylamine (2M i THF) but no conversion after 24 at 60 C.
Any suggestions ? Lewis acids ?
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Offline wildfyr

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Re: Epoxide opening with dimethylamine
« Reply #1 on: January 10, 2018, 12:24:58 PM »
Hmm that is a bit odd. This paper on using Lewis acid catalysts to ring open epoxides with alkyl amines might be useful


https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2004-817780
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