[dougschmidt]

I am seeking a test method and validation strategy for performance of dye ingress testing for container closure integrity verification. I understand the basics of the analysis, but looking for guidance on a few specifics.
1) best process for inserting microtubes for validation and number of sizes.
2) methylene blue dye formulation
3) pressure of vessel

Thanks

[wildfyr]

You are going to need to give us way more details about what exactly your are trying to do.

[Arkcon]

You can find an overview of the procedure by reviewing the USP recommendations: https://www.gmp-compliance.org/gmp-news/usp-chapter-1207-container-closure-integrity-testing

The specifics is specialized information, and people generally charge to develop and validate a method for a particular application.