or because of the D2O interactions?
Do you have any reputable reference that deuterium has significantly different chemical properties? Yes, it does react more slowly than H+, and yes, it does have some physical chemistry differences, I had heard of those. But I suspect you may be reaching with this interaction.
Why are you performing this? Just how enriched is your deuterated hydroxide? What's your solvent, and how deuterated is it?
If the answers aren't "very" than you can't expect much effect. If the answers are "not much at all" then you can't expect any effect. So why do
you expect an effect?