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Topic: Help troubleshooting a Buchwald-Hartwig amination?  (Read 1523 times)

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Offline minimumlong3

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Help troubleshooting a Buchwald-Hartwig amination?
« on: September 06, 2018, 04:53:11 PM »

Does anyone have any experience in Pd cross-coupling reactions that could help me? I'm trying to couple an aryl chloride (that has a alcohol protected by a TBDMS and an heterocycle) with a alkylamine with a phenol at the end of it. I'm getting weird products (multiple TBDMS signals when there should only be one). Also, my "product" tends to have a higher Rf than both of my reagents, if someone knows anything about this I would be very grateful!

Offline Borek

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Re: Help troubleshooting a Buchwald-Hartwig amination?
« Reply #1 on: September 06, 2018, 05:35:05 PM »
Please don't cross post.

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