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Author Topic: Seperation of two substances by column chromatography  (Read 607 times)

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skunny

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Seperation of two substances by column chromatography
« on: December 11, 2018, 10:37:30 PM »

Hey

I was really hoping somebody could help me out here, because i have no clue anymore what Else to try...

I am trying to seperate Ethyl-4-hydroxybenzoat and ethylvanillin....i Just don't find the right Solvent mixture....I have a good seperation between those substances, but only If i use ammonia and evaporating ammonia by a rotary evapirator doesnt work Out so Well...does anyone have an idea how i might successful:/? Thx!!!
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Babcock_Hall

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Re: Seperation of two substances by column chromatography
« Reply #1 on: December 12, 2018, 05:30:43 AM »

I have used rotary evaporation to remove aqueous ammonia on many occasions.  If it is not completely removed on the first pass, sometimes redissolving in a solvent and rotovapping again is necessary.  Triethylamine is an alternative, I suppose.

Sometimes removal of one solvent is aided by adding a second solvent to strip away the first.  I don't have any specific suggestions regarding ammonia in that regard, however.
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wildfyr

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Re: Seperation of two substances by column chromatography
« Reply #2 on: December 12, 2018, 06:32:55 AM »

Running the column with triethylamine or ammonia then doing an aqueous acid extraction at the end seems reasonable.
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