August 06, 2020, 02:43:14 PM
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Topic: Optimisation of elution conditions using designed experiments in HPLC  (Read 475 times)

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Offline Legolasas5

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Hello there,
I am trying to optimise HPLC method and I have a problem with 2 peaks that change their selectivity depending on elution conditions. Is it appropriate to have a negative resolution as a response in the DoE table if these peaks switch.
Thank you for your answers.

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