I haven't tried the nitrile yet, but I tried Red-Al on a amide-->amine reduction I have successfully done before with LAH.
While the reaction was beautifully clear, the workup wasn't as smooth as was the case with LAH.
With LAH, after refluxing overnight, I cooled to RT, added Glauber's salt-celite (my go to workup in general for LAH reductions), some DCM, filtered and rinsed with DCM, and pumped off the solvents. It gave me high purity crystalline material that could be used without further purification.
With the Red-Al reaction, after adding the Glauber's salt and stirring for an hour, the filtration was very slow (some gel, Al salts I presume) and the filtrate was cloudy, as if some of the salts went through the filter. I still need to pump off the volitiles on this reaction and check the purity by NMR.
I wonder if the ligand alcohols that render Red-Al soluble are causing these problems for the workup?
Anyone here who does the Glauber salt workups have any experience with Red-Al?