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6 Amino Penicillianic acid project
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Topic: 6 Amino Penicillianic acid project (Read 877 times)
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nickgamer49
Very New Member
Posts: 2
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6 Amino Penicillianic acid project
«
on:
February 28, 2022, 07:46:22 AM »
Hey! I am new to research and I am trying a project on the condensation to form phenylpenicillin (
https://pubchem.ncbi.nlm.nih.gov/compound/6-_Benzoylamino_penicillanic-acid
) from 6-APA (
https://pubchem.ncbi.nlm.nih.gov/compound/6-Aminopenicillanic-acid#section=Crystal-Structures
). I essentially mix 6apa dissolved in basic aqueous solution and benzoyl chloride in propanone to make the product. Because our lab doesnt have any spectroscopes and such, I acidify the solution and separate it with ethyl ethanoate. I am getting really bad yield with this process and a lot is hard to control. Does anyone have a better method or even a different topic involving the chemistry of 6APA? Thanks so much!
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Babcock_Hall
Chemist
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Re: 6 Amino Penicillianic acid project
«
Reply #1 on:
February 28, 2022, 08:26:35 AM »
Do you have access to SciFinder? If there is a better protocol, this would be one way to find it.
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rolnor
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Posts: 2223
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Re: 6 Amino Penicillianic acid project
«
Reply #2 on:
February 28, 2022, 09:44:07 AM »
Acid will open the beta-lactam. I agree, you need a protocoll.
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6 Amino Penicillianic acid project