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Topic: Ampicillin  (Read 3310 times)

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Offline AhmedEzatAlzawalaty

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Ampicillin
« on: March 15, 2007, 07:24:39 PM »
Why ampicillin is acid resistant
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Offline RaZ

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Re: Ampicillin
« Reply #1 on: March 15, 2007, 08:25:18 PM »
It's because the amine group (next to the phenyl) is an EWG.  This stops the oxygen from the carbonyl of the amide attacking the carbonyl on the B-lactam ring and opening it up.  Hope that helps.
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Offline EtOH

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Re: Ampicillin
« Reply #2 on: March 20, 2007, 07:12:24 PM »
Since when is amine an EWG? It's a strong activator which means it would stabilize by donating to the ring...
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