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Topic: Possible Friedel-Crafts Acylation?  (Read 3165 times)

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Offline GoldShadow

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Possible Friedel-Crafts Acylation?
« on: February 10, 2008, 03:34:30 AM »
I was reviewing for an upcoming exam and made up questions for myself to see if I could answer them, and I came up with the following intramolecular Friedel-Crafts acylation reaction:



Is this reaction possible or is it not? I think that it could be under certain conditions, but I have nothing to base this on.  Help would be appreciated.

Offline Yggdrasil

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Re: Possible Friedel-Crafts Acylation?
« Reply #1 on: February 10, 2008, 01:13:20 PM »
That cyclopropyl ring will be very highly strained since the ring forces the bond angles to be 60o while the sp2 carbons that make up the ring would prefer 120o bond angles.  If this product could form, it would be very unstable and react to form something else fairly quickly.

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