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Topic: Ethylenediamine dihydrochloride and methylpiperazine  (Read 3396 times)

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Offline wseguins

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Ethylenediamine dihydrochloride and methylpiperazine
« on: October 13, 2014, 03:03:19 PM »
Hello guys, I'm trying to synthesize methylpiperazine, but when ethylenediamine react with chloroacetone, the product formed is the ethylenediamine dihydrochloride.
Do you have any idea how to prevent the formation of this product? How do I induce the formation of methylpiperazine? The reaction is being made 273K.
Thanks!
« Last Edit: October 13, 2014, 03:14:31 PM by wseguins »

Offline Hunter2

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Re: Ethylenediamine dihydrochloride and methylpiperazine
« Reply #1 on: October 14, 2014, 01:34:44 AM »
Why using chloracetone. Normally its made by using ammonia and 1,2-Dichlorethane. I think ethylendiamine will react also with the Carbonyl carbon of Chloracetone.
Other possibility ios to reduce pyrazine with sodium.

Offline wseguins

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Re: Ethylenediamine dihydrochloride and methylpiperazine
« Reply #2 on: October 14, 2014, 08:13:14 AM »
Why using chloracetone. Normally its made by using ammonia and 1,2-Dichlorethane. I think ethylendiamine will react also with the Carbonyl carbon of Chloracetone.
Other possibility ios to reduce pyrazine with sodium.

I have used the chloroacetone because it is cheap is easy to prepare. In the laboratory have large amounts of ethylenediaminetetraacetic. So I decided to use the chloroacetone and ethylenediamine to produce something close to methylpiperazine. But this free chlorine reacting with ethylenediamine forming the compound by me commented.

I need to take this free chlorine to be able to induce the formation of methylpiperazine.

Offline Hunter2

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Re: Ethylenediamine dihydrochloride and methylpiperazine
« Reply #3 on: October 14, 2014, 08:21:21 AM »
I don't see any way to get your product. How should it work from Chloracetone and EDTA or you mean ethylendiamine to your product.

Chloride can be removed with Hydroxide.

Offline wseguins

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Re: Ethylenediamine dihydrochloride and methylpiperazine
« Reply #4 on: October 14, 2014, 08:27:12 AM »
I don't see any way to get your product. How should it work from Chloracetone and EDTA or you mean ethylendiamine to your product.

Chloride can be removed with Hydroxide.

I'm using ethylenediamine and chloroacetone. I did the reaction to cold. I will try to perform a reaction to hot. I will use the hydroxide to remove free chlorine.

How do you use this hydroxide solution?

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