That depends on how large your scale is. I have gone from 1g to 500g scale synthesis (at my industrial sponsor) with no real issues.
Does the reaction produce an exotherm? If so, you will need to cool it before doing your additions otherwise you might get a runaway exotherm that causes your solvent to boil over at best, and cause an explosion at worst.
Only after you are satisfied that any exotherm is no longer a risk should you start heating/warming the reaction, and do it slowly, with constant monitoring of temperature. Have an ice bath ready just in case.
Does the reaction evolve a gas (effervesce)? If so you need adequate venting and add things slowly and think about cooling. Do not add things in at once. Add them in portion wise. This goes for all reactions, whether they evolve gas or exotherm etc.
You can reduce solvent volumes on scale up. Say at 1 g scale you use 25 ml solvent, at 100 g you would think to use 250 ml, but you can get away with 150 mL depending on solubility.
Work up volumes also increase so special care needs to be taken, but again, you can get away with reducing solvent volumes a lot.
Larger glassware can be a bit difficult to work with also so just take care.
I cant think of much more but when I do I will update this post.