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High School Chemistry Forum / Re: Explain why isn't the slope in the purple,green, red equal?
« Last post by Babcock_Hall on Today at 05:10:18 PM »What are your thoughts?
https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01523
Granberg KL, J. Med Chem. 2019, 62, 3, 1385-1406.
One thing that attracted me to this method is that the ratio of the methyl sulfonamide to base to the chlorophosphate is 1:2:1; in other words, there is not the approximate twofold of excess of the methyl sulfonamide over the phosphorylating agent that I found in most other protocols. As to what is different, my speculation is that the steric bulk of this base prevents it from removing a proton from the product, which is more acidic than the starting material.
As far as I know, Valence shell electrons don't shield other valence shell electrons from the proton in the nucleus, and outer shell electrons don't shield inner shell electrons.This is incorrect. Valence shell electrons do shield other valence shell electrons; the effect is not as strong as the shielding effect by inner shell electrons, but it is not negligible. An outer shell electron may even spend some of its time closer to the nucleus than an inner shell electron, meaning a valence shell electron may exhibit a small shielding effect on an inner shell electron. Depending on your level of study, you may want to review structural models of the atom to have a better understanding of why this is the case.